Serveur d'exploration sur le lymphœdème

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[Stewart-Treves syndrome arising in post-traumatic lymphedema].

Identifieur interne : 00A927 ( Main/Exploration ); précédent : 00A926; suivant : 00A928

[Stewart-Treves syndrome arising in post-traumatic lymphedema].

Auteurs : B. Laguerre ; C. Lefeuvre ; P. Kerbrat ; M. Hassel

Source :

RBID : pubmed:10210761

Descripteurs français

English descriptors

Abstract

The authors report a case-history of lymphangiosarcoma or Stewart-Treves syndrome which occurred in a patient with posttraumatic lymphedema of the arm. He presented two recurrences after surgery which led to the decision of amputation. He is now disease free nine years after this treatment. Initially defined as "lymphangiosarcoma arising in chronic lymphedematous extremities after mastectomy for breast cancer", Stewart-Treves syndrome complicates rarely traumatic, postsurgical, postradiation, idiopathic, congenital or filarial lymphedema. Clinical diagnosis is based on nodular, purple and frequently multiple skin lesions on chronic lymphedema of the limb. A proliferating malignant endothelium with affinity for anti-factor-VIII is found on histological slides. The tumor aggressivity explains the short survival if no treatment is given. Stewart-Treves syndrome prognosis is poor, with the occurrence of multiple local recurrences and pulmonary metastasis. On account of its rarity, there is no therapeutic consensus. In localized stage, radical surgery is usually performed. Conservative treatment with complete tumour removal and postoperative radiotherapy has not been yet evaluated. In metastatic or locally advanced tumours, it is necessary to study the benefit of cytotoxic drugs like anthacyclins and ifosfamide known to be effective on soft tissue sarcomas.

PubMed: 10210761


Affiliations:


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Le document en format XML

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<term>Amputation</term>
<term>Arm Injuries (complications)</term>
<term>Fractures, Bone (complications)</term>
<term>Hand</term>
<term>Humans</term>
<term>Lymphangiosarcoma (etiology)</term>
<term>Lymphangiosarcoma (pathology)</term>
<term>Lymphangiosarcoma (surgery)</term>
<term>Lymphedema (complications)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prognosis</term>
<term>Skin Transplantation</term>
<term>Syndrome</term>
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<term>Adulte d'âge moyen</term>
<term>Amputation chirurgicale</term>
<term>Fractures osseuses ()</term>
<term>Humains</term>
<term>Lymphangiosarcome ()</term>
<term>Lymphangiosarcome (anatomopathologie)</term>
<term>Lymphangiosarcome (étiologie)</term>
<term>Lymphoedème ()</term>
<term>Main</term>
<term>Mâle</term>
<term>Pronostic</term>
<term>Syndrome</term>
<term>Transplantation de peau</term>
<term>Traumatismes du bras ()</term>
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<term>Lymphangiosarcome</term>
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<term>Arm Injuries</term>
<term>Fractures, Bone</term>
<term>Lymphedema</term>
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<term>Lymphangiosarcoma</term>
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<div type="abstract" xml:lang="en">The authors report a case-history of lymphangiosarcoma or Stewart-Treves syndrome which occurred in a patient with posttraumatic lymphedema of the arm. He presented two recurrences after surgery which led to the decision of amputation. He is now disease free nine years after this treatment. Initially defined as "lymphangiosarcoma arising in chronic lymphedematous extremities after mastectomy for breast cancer", Stewart-Treves syndrome complicates rarely traumatic, postsurgical, postradiation, idiopathic, congenital or filarial lymphedema. Clinical diagnosis is based on nodular, purple and frequently multiple skin lesions on chronic lymphedema of the limb. A proliferating malignant endothelium with affinity for anti-factor-VIII is found on histological slides. The tumor aggressivity explains the short survival if no treatment is given. Stewart-Treves syndrome prognosis is poor, with the occurrence of multiple local recurrences and pulmonary metastasis. On account of its rarity, there is no therapeutic consensus. In localized stage, radical surgery is usually performed. Conservative treatment with complete tumour removal and postoperative radiotherapy has not been yet evaluated. In metastatic or locally advanced tumours, it is necessary to study the benefit of cytotoxic drugs like anthacyclins and ifosfamide known to be effective on soft tissue sarcomas.</div>
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